December 9, 2016
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Vaccine Records of Internationally Adopted Children May Not Reflect Protection Against Disease

Vaccine Records of Internationally Adopted Children May Not Reflect Protection Against Disease


Other studies on immunization also highlighted in Archives of Pediatrics & Adolescent Medicine theme issue

CHICAGO, MAY 4, 2009 – Children adopted from countries such as Russia, China and Guatemala may not be protected against polio, measles or other diseases despite records indicating they have been immunized, according to a report in the May issue of Archives of Pediatrics & Adolescent Medicine, a theme issue on vaccines. Senior and corresponding author Anna Maria Mandalakas, M.D., M.S., explains the findings in an audio interview available here.

The issue features several research papers and commentaries about immunizations, on topics such as reducing the pain infants experience when getting vaccinated, introducing the vaccine against human papillomavirus to developing nations and implementing strategies to increase the number of children who receive life-saving immunizations.

According to background information in the article on international adoptions, U.S. families have adopted almost 250,000 foreign-born children in the last 15 years. Many of these children were living in orphanages or other institutional settings with few resources and are likely to have incomplete immunization records or none at all. When valid written records do exist, the American Academy of Pediatrics Committee on Infectious Disease advises that they could be considered as evidence of previous vaccination. However, there are reasons to suspect that these records may not accurately reflect immunity, including "documentation inaccuracies, lack of vaccine potency and impaired immune response, possibly due to stress or malnutrition."

Dr. Mandalakas, Emaculate Verla-Tebit, Ph.D., and colleagues at Case Western Reserve University, Cleveland, obtained data from 465 children who visited the International Adoption Clinic at Rainbow Babies and Children's Hospital between 2001 and 2006 and who presented for care within 180 days of arrival to the United States. Most of the adopted children came from Russia (41.7 percent), China (20.9 percent) or Guatemala (15.7 percent). Immunization records were available for 397 (85.4 percent) of adoptees (average age 19.4 months). Blood samples were obtained and tested for evidence of immunity against diphtheria, tetanus, measles, hepatitis B and polio.

Evidence of immunity was found in:

* 87.2 percent of the 203 children with three or more tetanus vaccinations
* 94.6 percent of the 205 children with three or more diphtheria vaccinations
* a differing number of the 216 children with three or more polio vaccines based on disease type—58.3 percent against polio type 1, 82.4 percent against polio type 2, and 51.9 percent against polio type 3
* 94.1 percent of the 170 children with two or more hepatitis B vaccinations
* 80.8 percent of the 99 children with measles vaccinations

Children from China were less likely to have immunity than those from Russia. A total of 5.5 percent of the adoptees had acute malnutrition and 15.4 percent had chronic malnutrition; however, nutrition status was not associated with immunity.

"Our results suggest that the predictive value of immunization records in international adoptees may be limited and associated with birth country," the authors write. "Reasons that have been proposed include falsification of vaccine certificates, inaccurate entries and lack of vaccine potency."

Revaccination may be a cost-effective option for parents whose children do not show immunity, the authors note. Parents of children in the current study chose to revaccinate between 5 percent and 21 percent of the time, depending on the vaccine type. "Immunization records should not be accepted as evidence of protective immunity. Parents should be well informed and supported to choose between revaccination or vaccination, based on serologic [blood] testing," they conclude.
(Arch Pediatr Adolesc Med. 2009;163[5]473-479.)

Editor's Note: This study was supported by a grant from the National Institutes of Health. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Other papers published in the issue find that:

* Infants' pain response to vaccines varies based on the order in which the vaccines are administered
* A social marketing strategy may be useful in battling negative public perceptions about vaccines
* Pediatricians could play a greater role in immunizing adults who have contact with young children
* In times of vaccine shortages, pediatric practices with systems to track high-risk children may help ensure they receive needed immunizations first
* Accelerating the dosing schedules of some vaccines appears to increase immunization rates and also may reduce disease burden
* Strategies for introducing new vaccines—especially those with cultural sensitivities, such as the human papillomavirus (HPV) vaccine—should address community concerns through effective communication, appropriate delivery and targeted advocacy
* Although progress has been made in addressing disparities in immunizations and vaccine-preventable diseases among American Indian and Alaskan Native children as well as among low-income children, ongoing efforts will be necessary to maintain that progress.
 



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