Today's Date: February 3, 2023
General Dynamics Elects Richard Clarke to Board of Directors   •   Government of Canada to support clean air and local economic growth by powering federal operations in Alberta and Saskatchewan w   •   The Law Offices of Frank R. Cruz Reminds Investors of Looming Deadline in the Class Action Lawsuit Against Veru Inc. (VERU)   •   The Law Offices of Frank R. Cruz Reminds Investors of Looming Deadline in the Class Action Lawsuit Against Affirm Holdings, Inc.   •   INVESTOR ALERT: Law Offices of Howard G. Smith Announces the Filing of a Securities Class Action on Behalf of National Vision Ho   •   RESIDES CEO COLETTE STEVENSON NAMED 2023 RISMEDIA REAL ESTATE NEWSMAKER   •   Experiences of Black Women With Breast Cancer Highlight Need for Better Care, Improved Outcomes   •   Conemaugh Miners Medical Center and Conemaugh Meyersdale Medical Center Achieve Designation as Lifepoint Health National Quality   •   Urban One Inc's Reach Media Announces R&B Superstar Ralph Tresvant of New Edition as Host of "Love and R&B"   •   TWO PUBLIC ALLIES ALUMNI JOIN THE NATIONAL BOARD OF DIRECTORS   •   INVESTOR ALERT: Law Offices of Howard G. Smith Announces the Filing of a Securities Class Action on Behalf of Invivyd, Inc. f/k/   •   American Marketing Association San Diego Launches New Sandie Awards and Opens Call for Entries   •   The Law Offices of Frank R. Cruz Reminds Investors of Looming Deadline in the Class Action Lawsuit Against NeoGenomics, Inc. (NE   •   Scottsdale Tesla Drivers Club and PS Academy Arizona Work Together on Tesla Cybertruck Build   •   Worldwide Shipments of Tablets and Chromebooks Declined Sharply in 2022, According to IDC Tracker   •   Introduction of Diagnostic and Supplemental Imaging Legislation Would Benefit Thousands of Marylanders   •   US Fertility founding partner Shady Grove Fertility (SGF) announces Egg Freezing for Surgical Residents Program in celebration o   •   SHAREHOLDER ACTION ALERT: The Schall Law Firm Encourages Investors in Honda Motor Co., Ltd. with Losses of $100,000 to Contact t   •   Hyundai and TEN Advertising Develop Their First Asian American Campaign "My Love, My Son-in-Law" for the Tucson SUV   •   Glancy Prongay & Murray LLP, a Leading Securities Fraud Law Firm, Announces the Filing of a Securities Class Action on Behal
Bookmark and Share

Quanterix’s Simoa® Technology Drives Advances in Alzheimer’s Disease Research Presented at 2022 Clinical Trials

BILLERICA, Mass. , December 05 /Businesswire/ - Quanterix Corporation (NASDAQ: QTRX), a company fueling scientific discovery through ultrasensitive biomarker detection, today announced that its Simoa® technology has powered important advances in ongoing clinical trials for the treatment of Alzheimer’s disease (AD). The findings were presented at the 15th Clinical Trials on Alzheimer’s Disease (CTAD) conference held in San Francisco, CA from November 29 to December 2, 2022.

In a historic moment in the fight against Alzheimer’s disease, Eisai Co., Ltd. and Biogen Corporation presented results from the Phase 3 clinical trial (Clarity AD) of lecanemab, an investigational drug aimed at slowing the progression of cognitive decline caused by AD. Target engagement and activity of the drug in downstream processes was explored with a panel of fluid biomarkers, including plasma pTau-181, GFAP and NfL, using Quanterix’s ultrasensitive Simoa assay kits. A report of the trial’s findings can be found in the New England Journal of Medicine.

In other encouraging data for AD therapeutics, topline results from Eli Lilly and Company’s Phase 3 TRAILBLAZER-ALZ 4 study findings were presented for donanemab, an investigational antibody that targets a modified form of beta amyloid plaque called N3pG. An updated readout of this ongoing trial is expected at the 2023 AD/PD™ meeting next spring.

In addition, a presentation was given on Janssen's Simoa plasma pTau-217 assay as a precision prescreening tool in the Phase 2 Autonomy anti-tau monoclonal Ab trial in early Alzheimer's disease. The talk highlighted the correlation of the assay with amyloid and tau PET status and pointed out its utility as a prescreening tool. The data can be found in this Alzheimer's Association research article. Researchers at Austin Health, Melbourne, also presented a paper looking at the two-year prognostic utility of Janssen’s Simoa pTau-217 assay in the Alzheimer's continuum.

An international CTAD Task Force on Blood Biomarkers led by academic and industry leaders was convened at CTAD on November 29 to explore the utility of plasma biomarkers in AD trials. During the session, topics of discussion included the use of blood-based biomarkers as a replacement for PET as a clinical trial entry criteria and for drug effects monitoring. The stature of amyloid PET, an expensive and not widely accessible gold standard testing modality for amyloid pathology, was questioned in view of the emerging high accuracy of plasma biomarkers. A CTAD blood-based biomarker workgroup was also convened on December 1 with a charter to map facilitators and barriers toward identifying specific workstreams to help drive the implementation of blood-based biomarkers in U.S. clinical practice. The project is scoped to provide meaningful work products in 2023 to facilitate clinical implementation of blood-based biomarkers.

“The results from Eisai’s Clarity AD clinical trial represent an exciting milestone for the treatment of Alzheimer’s disease,” said Masoud Toloue, CEO at Quanterix. “We’ve also seen that the use of blood-based biomarkers is growing rapidly in this field and will be integral in future therapeutic trial designs, as well as Alzheimer’s diagnostics. We are pleased that our technology is playing a key role in this rapid progress, including trial prescreening and enrollment of larger, more diverse populations, enhanced monitoring of drug effects and improvements in the diagnostic journey for Alzheimer’s patients.”

“We look forward to continuing to arm the pharma, academia and research fields with the tools to fuel breakthroughs in drug development and clinical validation for devastating neurodegenerative diseases like Alzheimer’s. These tools include our available CLIA-validated test for blood pTau-181 and a CLIA-validated test for NfL available in the first half of next year. Both of these tests were designated Breakthrough Devices by the FDA and are on IVD paths pending completion of clinical validation studies,” continued Toloue.

For more information about Quanterix’s work in neurology, please visit https://www.quanterix.com/therapeutic-areas/neurology/.

About Quanterix

From discovery to diagnostics, Quanterix’s ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. The Company’s Simoa® technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Limit of Quantification (LoQ) of conventional analog methods. Its industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology and infectious disease. Quanterix has been a trusted partner of the scientific community for nearly two decades, powering research published in more than 2,000 peer-reviewed journals. Find additional information about the Billerica, Massachusetts-based company at https://www.quanterix.com or follow us on Twitter and LinkedIn.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "plan," "anticipate," "estimate," "intend" and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. Forward-looking statements in this news release are based on Quanterix’ expectations and assumptions as of the date of this press release. Each of these forward-looking statements involves risks and uncertainties. Factors that may cause Quanterix’ actual results to differ from those expressed or implied in the forward-looking statements in this press release are discussed in Quanterix’ filings with the U.S. Securities and Exchange Commission, including the "Risk Factors" sections contained therein. Except as required by law, Quanterix assumes no obligation to update any forward-looking statements contained herein to reflect any change in expectations, even as new information becomes available.


STORY TAGS: Conference, Product/Service, Survey, United States, North America, Mental Health, Health, Clinical Trials, Research, Science, Pharmaceutical, Biotechnology, California, Massachusetts,

Video

White House Live Stream
LIVE VIDEO EVERY SATURDAY
alsharpton Rev. Al Sharpton
9 to 11 am EST
jjackson Rev. Jesse Jackson
10 to noon CST


Video

LIVE BROADCASTS
Sounds Make the News ®
WAOK-Urban
Atlanta - WAOK-Urban
KPFA-Progressive
Berkley / San Francisco - KPFA-Progressive
WVON-Urban
Chicago - WVON-Urban
KJLH - Urban
Los Angeles - KJLH - Urban
WKDM-Mandarin Chinese
New York - WKDM-Mandarin Chinese
WADO-Spanish
New York - WADO-Spanish
WBAI - Progressive
New York - WBAI - Progressive
WOL-Urban
Washington - WOL-Urban

Listen to United Natiosns News