Today's Date: June 9, 2023
A New Era of Three-Row Luxury: The First-Ever Lexus TX   •   Children's Miracle Network Hospitals® Celebrates 40th Anniversary with Celebrity Friends and Supporters   •   Saudi Arabia: Modern means of transportation for easier Hajj   •   Forbes names Sun Life U.S. a Best Employer for Diversity   •   Stallergenes Greer Showcases Clinical Relevance and Persisting Benefits of Its Allergen Immunotherapy Treatments at 2023 EAACI C   •   TIO EQUITY ALERT: ROSEN, A LONGSTANDING LAW FIRM, Encourages Tingo Group, Inc. Investors with Losses in Excess of $100K to Secur   •   Sophisticated Utility Vehicle: all-new 2024 Lexus GX Redefines SUV   •   CGTN: China stresses green development, ethnic unity in modernization drive   •   The Law Offices of Frank R. Cruz Announces the Filing of a Securities Class Action on Behalf of Tingo Group, Inc. (TIO) Investor   •   USCIB Releases Pride Month Statement, Supporting Equality and Inclusion   •   AHF Applauds President Biden’s Strong Defense of LGBTQ+ Rights   •   IgGenix Demonstrates Potential for an IgG4 Monoclonal Antibody-based Approach to Treating Peanut Allergy   •   TEXAS CAPITAL ALERT: Bragar Eagel & Squire, P.C. is Investigating Texas Capital Bancshares, Inc. on Behalf of Texas Capital   •   Fairmont Mayakoba to host exclusive 2023 pride celebration   •   SoftwareReviews Reveals the Top ESG Software Solutions That Enable Organizations to Build a Culture of Purpose and Sustainabilit   •   Fate ALERT: Bragar Eagel & Squire, P.C. is Investigating Fate Therapeutics, Inc. on Behalf of Long-Term Stockholders and Enc   •   Ventas Realty, Limited Partnership Announces Upsize and Pricing of $750 Million of Exchangeable Senior Notes   •   Providing LGBTQI+ people with a safe home in Canada   •   Influencers, Youth Mentorship Organizations and Concerned Citizens Make a Summer Plan to Stop the Violence in Chicago   •   ADVANCE AUTO PARTS ALERT: Bragar Eagel & Squire, P.C. is Investigating Advance Auto Parts, Inc. on Behalf of Advance Auto Pa
Bookmark and Share

Study by Karmanos and Georgetown researchers find relationship between discrimination and frailty in Black cancer survivors

Study by Karmanos and Georgetown researchers find relationship between discrimination and frailty in Black cancer survivors

PR Newswire

DETROIT, March 20, 2023 /PRNewswire/ -- Discrimination experienced by Black people can affect their health and increase their frailty, which can be particularly impactful for cancer survivors, according to a new study by researchers at Barbara Ann Karmanos Cancer Institute and colleagues at Georgetown University's Lombardi Comprehensive Cancer Center in Washington, DC. "Association between major discrimination and deficit accumulation in African American cancer survivors: The Detroit Research on Cancer Survivors Study" was published in Cancer, a peer-reviewed journal of the American Cancer Society. The researchers assessed frailty by several factors, including whether a participant had several chronic diseases, poor muscle strength and difficulty performing activities of daily living.

"Discrimination can act as a chronic stressor which can throw the body off balance, resulting in increases in blood pressure, heart rate, metabolism, inflammation, and numerous other factors. These stressors can also increase rates of aging, leading to greater risk of frailty," said the study's lead investigator, Jeanne Mandelblatt, M.D., MPH, director of the Georgetown Lombardi Institute for Cancer and Aging Research. "We hypothesize that discrimination can lead to an older biological age than a person's actual chronological age. This is important to understand as there have been virtually no studies of the relationships between discrimination and aging in the setting of cancer survivorship."

The investigators looked at associations between discrimination and frailty among 2,232 Black breast, lung, prostate and colorectal cancer survivors within five years of their diagnoses and were no longer being treated for their cancers. Survivors were 62 years of age on average (with ages ranging from 23 to 84) at the time of the study, but they may have experienced discrimination over many decades of their lives. All participants were part of the Detroit Research on Cancer Survivors (ROCS), the largest U.S. study of Black cancer survivors.

The researchers surveyed the participants, via phone, in writing, or online about any aging-related diseases they had, their ability to maintain a healthy lifestyle, and most importantly, about major discrimination events they may have experienced over their lifetimes, specifically targeting seven areas:

  • being unfairly fired or denied a promotion in their job;
  • not being hired for a job;
  • being unfairly stopped, searched, questioned, physically threatened or abused by police officers;
  • being unfairly discouraged by a teacher or advisor from continuing their education;
  • unfairly receiving worse medical care than other people;
  • being prevented from moving into a neighborhood because a landlord or realtor refused to sell or rent them a house or an apartment; and/or
  • moved into a neighborhood where neighbors made life difficult.

Based on the survey results, the majority of cancer survivors were classified as either prefrail (42.7%), meaning they had some health difficulties, or frail (32.9%). Only 24.4% of those surveyed had few or no signs of frailty. When queried about the seven discrimination areas, 63.2% of the participants reported experiencing major discrimination, with an average respondent reporting 2.4 types of discrimination.

"For those cancer survivors who reported four to seven types of discrimination events, we observed a large, clinically meaningful increase in frailty scores compared to survivors with fewer discrimination events," explains Mandelblatt, also a professor of oncology and medicine at the Georgetown University School of Medicine. "Significantly, this pattern of discrimination affecting frailty was consistent across the four types of cancer surveyed, indicating that discrimination is an important factor to study and understand in Black cancer survivors in order to improve their quality and length of life."

"Our results indicate that after considering the effects of traditional factors on poor health, such as income, education and types of cancer treatment, discrimination was a significant factor explaining frailty and it acted independently of the other variables," said Ann Schwartz, Ph.D., MPH, co-lead author on the paper and co-principal investigator of the Detroit ROCS. "Regardless of whether you were rich or poor, if you experienced more discrimination, you had greater frailty."

Schwartz is also professor and associate chair of oncology at Wayne State University (WSU) School of Medicine and deputy center director and executive vice president for research and academic affairs at Karmanos.

For their next steps, the researchers hope to study the relationships between major discrimination, other chronic life stressors, and markers of biological aging and test how cancer and its treatment further contribute to biological aging among racial and ethnic minorities.

"We have long since recognized the impact of discrimination on health and well-being in Black communities," says study co-author Lucile Adams-Campbell, Ph.D., a professor of oncology and associate director for Minority Health and Health Disparities Research at Georgetown Lombardi. "We hope that this study leads to more discussions between providers and their patients about the types of discrimination they have experienced and gives providers a greater understanding of how discrimination impacts frailty."

Additional authors include the following members of the Population Studies and Disparities Research Program at Karmanos: Julie Ruterbusch, MPH, research assistant at WSU; Hayley Thompson, Ph.D., associate center director of Community Outreach and Engagement, faculty supervisor of the Office of Cancer Health Equity and Community Engagement (OCHECE) at Karmanos, professor of oncology and leader of the Center for Health Equity and Community Knowledge in Urban Populations (CHECK-UP) at WSU; and Kristen Purrington, Ph.D., MPH, associate professor at WSU School of Medicine.

Xingtao Zhou, MS, and Traci Bethea, Ph.D., at Georgetown Lombardi were also authors of this study.

This research was supported by National Cancer Institute grants, a National Institute on Aging grant, and the Epidemiology Research Core and the National Cancer Institute Center Grant awarded to the Barbara Ann Karmanos Cancer Institute and Wayne State University.

About the Barbara Ann Karmanos Cancer Institute

Karmanos Cancer Institute is a leader in transformative cancer care, research and education through courage, commitment and compassion. The Karmanos vision is a world free of cancer. As part of McLaren Health Care, Karmanos is the largest provider of cancer care and research in Michigan. For more than 75 years, the administrative and research headquarters, along with the premier specialty cancer hospital, have been located in downtown Detroit. With 16 network sites, Karmanos delivers world-renowned care and access to clinical trials throughout Michigan and northern Ohio. The National Cancer Institute recognizes Karmanos as one of the best cancer centers in the nation with a comprehensive cancer center designation. Its academic partnership with the Wayne State University School of Medicine provides the framework for cancer research and education – defining new standards of care and improving survivorship. For more information, call 1-800-KARMANOS (800-527-6266) or visit Follow Karmanos on FacebookTwitterLinkedIn and YouTube.

Cision View original content to download multimedia:

SOURCE Karmanos Cancer Institute

Back to top
| Back to home page

White House Live Stream
alsharpton Rev. Al Sharpton
9 to 11 am EST
jjackson Rev. Jesse Jackson
10 to noon CST


Sounds Make the News ®
Atlanta - WAOK-Urban
Berkley / San Francisco - KPFA-Progressive
Chicago - WVON-Urban
KJLH - Urban
Los Angeles - KJLH - Urban
WKDM-Mandarin Chinese
New York - WKDM-Mandarin Chinese
New York - WADO-Spanish
WBAI - Progressive
New York - WBAI - Progressive
Washington - WOL-Urban

Listen to United Natiosns News